Table 1.
Basic characteristics of clinical trials evaluating the effect of topical aminophylline in local fat reduction.
| Author, year | Study location | Number of participants | Participants’ characteristics | Pharmaceutical form | Other ingredients | Body area(s) studied |
|---|---|---|---|---|---|---|
| Artz and Dinner (17) | United States | 12 volunteers | – | Gel | – | Lateral thighs and buttocks |
| Greenway et al. (18) (Trial 2) |
United states | 5 women | Participants were more than 20% above their desirable weights. | Ointment | • Aquaphor® base • Forskolin • Yohimbine |
Thighs |
| Greenway et al. (18) (Trial 3-3) |
United states | 5 women | Participants were greater than 20% overweight. | Ointment | Aquaphor® base | Thighs |
| Greenway et al. (18) (Trial 4) |
United states | 23 women | Participants were greater than 20% overweight. | Ointment | Aquaphor® base | Thighs |
| Greenway et al. (18) (Trial 5) |
United states | 11 women | • All participants felt that their thighs were undesirably fat. • Some women wanted to lose weight while others were satisfied with their present weight. |
Cream | – | Thighs |
| Greenway et al. (18) (Trial 6) |
United states | 12 women | • All participants felt that their thighs were undesirably fat. • Some women wanted to lose weight while others were satisfied with their present weight. |
Cream | – | Thighs |
| Collis et al. (25) | England | 17 women | Participants were over 18 years old with cellulite of the thighs and buttocks. | Cream | 10% glycolic acid | Thighs and buttocks |
| Caruso et al., (26) | United states | 25 men and women | • All participants were obese and overweight with a BMI greater than 27 kg/m2. • Participants’ age was between 21 and 65 years. • Participants had android fat distribution (characterized by a waist to hip ratio >0.80 in women or >1.0 in men). |
Cream | – | Waist |
| Escalante et al. (27) | United states | 7 women | – | Lotion | • Caffeine, • Yohimbe • L-Carnitine • Gotu kola |
Thighs |