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. 2023 Feb 16;14:1065181. doi: 10.3389/fimmu.2023.1065181

Figure 4.

Figure 4

The roles of piscine GSDME in inflammasome signaling, pyroptosis and bacterial clearance. GSDME mediates pyroptosis following cleavage by inflammatory caspases. In the zebrafish and turbot, GSDMEa and GSDMEb were obtained. Zebrafish caspy2 cleaves GSDMEa/b for resulting in pyroptosis and bacterial clearance of E. tarda or E. piscicida. Turbot caspase-3/7 cleave GSDMEa for resulting in pyroptosis and bacterial clearance of V. harveyi. The inflammatory caspase in the turbot cleaves GSDMEb for resulting in pyroptosis and bacterial clearance of E. piscicida. In the tongue sole, CASP1, CASP3 and CASP7 cleave GSDME for resulting in pyroptosis and bacterial clearance of E. coli.