Table 2.
Demographics, clinical, and polysomnographic data per positional group.
| Variable | spOSA | siOSA | Lateral PP | NPP |
|---|---|---|---|---|
| N (%) | 257 (29.8) | 293 (34.0) | 35 (4.1) | 276 (32.1) |
| Sex, n (%) | ||||
| Male | 156 (60.7)* | 149 (50.9) | 13 (37.1) | 143 (52.9) |
| Race/ethnicity, n (%) | ||||
| White, Caucasian | 96 (37.4) | 122 (41.6) | 15 (42.9) | 86 (31.2) |
| Chinese American | 34 (13.2) | 42 (14.3) | 1 (2.9) | 27 (9.8) |
| Black, African American | 64 (24.9) | 67 (22.9) | 12 (34.3) | 90 (32.6) |
| Hispanic | 63 (24.5) | 62 (21.1) | 7 (20.0) | 73 (27.4) |
| Cigarette smoking, n (%) | ||||
| Never | 124 (48.2) | 173 (48.8) | 13 (37.1) | 120 (43.5) |
| Former | 109 (42.4) | 132 (45.1) | 18 (51.4) | 142 (51.4) |
| Current | 23 (8.9) | 17 (5.8) | 3 (8.6) | 14 (5.1) |
| None | 0 (0) | 1 (0.3) | 1 (2.9) | 0 (0.0) |
| Hypertension, n (%) | ||||
| No | 104 (40.5) | 149 (50.9)* | 11 (31.4) | 96 (34.8) |
| Yes | 153 (59.5) | 144 (49.1)* | 23 (65.7) | 180 (65.2) |
| None | 0 (0) | 0 (0) | 1 (2.9) | 1 (0.3) |
| Asthma, n (%) | ||||
| No | 250 (97.3) | 283 (96.6) | 32 (91.4) | 262 (94.9) |
| Yes | 6 (2.3) | 9 (3.1) | 2 (8.6) | 14 (5.1) |
| Don’t know | 0 (0.0) | 0 (0) | 0 (0) | 0 (0) |
| None | 1 (0.4) | 1 (0.3) | 0 (0) | 0 (0) |
| ESS, n (%) | ||||
| Normal (0–10) | 209 (81.3) | 263 (89.8) | 29 (88.4) | 228 (82.6) |
| Mild (11–14) | 29 (11.3) | 23 (7.8) | 3 (8.6) | 36 (13.0) |
| Moderate (15–17) | 11 (4.3) | 3 (1.0) | 2 (5.7) | 8 (2.9) |
| Severe (18–24) | 4 (1.6) | 2 (07.) | 1 (2.9) | 2 (0.7) |
| None | 4 (1.6) | 2 (0.7) | 0 (0) | 2 (0.7) |
| Emphysema or COPD,** n (%) | ||||
| No | 250 (97.3) | 288 (98.3) | 34 (97.1) | 270 (97.8) |
| Yes | 6 (2.3) | 4 (1.4) | 1 (2.9) | 5 (1.8) |
| Don’t know | 0 (0) | 1 (0.3) | 0 (0) | 1 (0.4) |
| None | 1 (0.4) | 0 (0) | 0 (0) | 0 (0.0) |
| Atrial fibrillation, n (%) | ||||
| No | 253 (98.4) | 289 (98.7) | 34 (97.1) | 271 (98.2) |
| Yes | 3 (1.2) | 1 (0.3) | 0 (0) | 4 (1.4) |
| None | 1 (0.4) | 3 (1.0) | 1 (2.9) | 1 (0.4) |
| AHI, median (IQR), events/h | 19.9 (18.2)* | 9.4 (6.4)* | 11.2 (8.6)* | 17.2 (22.6)* |
| Supine | 39.9 (32.5)* | 18.6 (16.8)* | 3.8 (4.6)* | 19.9 (27.0)* |
| Nonsupine | 9.8 (9.0)* | 1.8 (2.7)* | 13.7 (13.3)* | 16.0 (20.2)* |
| REM | 5.1 (4.6)* | 3.2 (3.8)* | 6.2 (4.6) | 5.9 (5.4)* |
| NREM | 14.8 (15.8)* | 5.8 (6.4)* | 4.0 (4.7)* | 10.6 (21.4)* |
| Demographics, median (IQR) | ||||
| Age, y | 67 (14) | 67 (15) | 66 (11.5) | 68 (14) |
| BMI, kg/m2 | 29.0 (5.9)* | 26.9 (5.2)* | 31.4 (4.9)* | 30.5 (8.0)* |
| No. of events, median (IQR) | ||||
| Apneas | 24 (44.0) | 12.0 (27.0) | 10.0 (22.5) | 15.5 (44) |
| Hypopneas | 92.0 (77.0) | 44.0 (33.0) | 51.0 (57.0) | 80.0 (89.5) |
| Longest event, median (IQR) | ||||
| Apnea, s | 41.4 (25.5)* | 34.3 (20.9)* | 30.7 (18.9) | 37.7 (25.5) |
| Hypopnea, s | 49.6 (19.2) | 46.9 (25.2) | 44.6 (30.3) | 46.6 (18.7) |
| Sleep efficiency, median (IQR) | ||||
| Average, min | 91.0 (5.0) | 92.1 (4.6) | 91.4 (3.5) | 91.5 (4.5) |
| Standard deviation, min | 2.5 (1.9) | 2.3 (1.7) | 2.4 (1.5) | 2.4 (1.6) |
| Body shape, median (IQR) | ||||
| Waist, cm | 100 (16.0)* | 95.9 (14.5)* | 103.3 (18.6) | 104 (18.2)* |
| Hip, cm | 104.2 (13.0)* | 101.8 (11.0)* | 109.5 (10.3)* | 108.5 (18.5)* |
| TST, median (IQR), h | 6.3 (1.7) | 6.3 (1.2) | 6.4 (1.4) | 6.3 (1.3) |
| Supine | 2.2 (2.2)* | 3.1 (2.4)* | 1.5 (1.6)* | 2.3 (2.5)* |
| Nonsupine | 3.9 (2.2)* | 3.0 (2.3)* | 4.7 (2.3)* | 3.6 (2.2)* |
| REM | 1.1 (0.7) | 1.2 (0.6)* | 1.2 (0.7) | 1.1 (0.6) |
| NREM | 5.1 (1.4) | 5.0 (1.1) | 5.2 (1.2) | 5.3 (1.2) |
Demographics, clinical and polysomnographic data of 861 MESA patients with OSA, divided into 4 groups: spOSA, siOSA, Lateral PP, and NPP. *Statistically significantly different between the other 2 or 3 OSA phenotype groups. Statistical difference was computed using Kruskal-Wallis H-test for independent samples, and significance was considered for P values < .05. **Self-reported. AHI = apnea-hypopnea index, BMI = body mass index, COPD = chronic obstructive pulmonary disease, ESS = Epworth Sleepiness Scale, IQR = interquartile range, MESA = Multi-Ethnic Study of Atherosclerosis, NPP = non-positional patients, NREM = non–rapid eye movement, OSA = obstructive sleep apnea, PP = positional patients, REM = rapid eye movement, siOSA = supine isolated OSA, spOSA = supine predominant OSA, TST = total sleep time.