Table 1.
A summary of all the Enterobacterales and P. aeruginosa isolates selected for the in vivo efficacy studies. All isolates were examined in the in vivo efficacy of cefepime/taniborbactam human-simulated exposures studies. Isolates designated by bolded CAIRD IDs were also examined in taniborbactam dose-ranging studies
| Isolate | MIC (mg/L) | β-Lactamase encoded | |||
|---|---|---|---|---|---|
| CAIRD ID | Source | Source ID | Cefepime | Cefepime/taniborbactam | |
| EC 747 | ATCC | BAA 2340 | 512 | 2 | KPC |
| EC 753 a | IHMA | 1904038 | >512 | 2 | CTX-M-15 |
| EC 755 a,b | IHMA | 1886025 | >512 | 16 | CTX-M-15, EC-TYPE, OXA-1, TEM-1 |
| ECL 108 | CDCe | 0163 | >512 | 2 | KPC-2, ACT-7, CTX-M-15, OXA-1, TEM-1B |
| KP 647 | CDCe | 0112 | >512 | 0.12 | KPC-3 |
| KP 679 | CDCe | 0066 | >512 | 4 | OXA-232, OXA-9, TEM-1A, CTX-M-15, OXA-1 |
| KP 681 c | CDCe | 0075 | >512 | 1 | CTX-M-15, OXA-1, OXA-232, SHV-1 |
| KP 731 d | CAIRD | >512 | 1 | SHV-11, TEM-1, KPC-3 | |
| PSA 1711 | CDCe | 0518 | 128 | 16 | PDC-103, KPC-2 |
| PSA 1714 | CDCe | 0528 | 32 | 4 | PDC-1 |
| PSA 1715 | CDCe | 0529 | 16 | 4 | PDC-5 |
| PSA 1844 | CDCe | 0356 | >512 | 2 | KPC-2, PDC-42 |
| EC 720 | CDCe | 0437 | >512 | 16 | CTX-M-15, OXA-1 |
| EC 748 | CDCe | 0001 | 512 | 2 | ESC-35, OXA-1, KPC-3 |
| ECL 124d | CAIRD | >512 | 8 | TEM-OSBL, CTX-M-15, ACT-7 | |
| KP 579d | CAIRD | >512 | 16 | SHV-11, TEM-1, CTX-M-15, OXA-48 | |
| KP 744d | CAIRD | >512 | 4 | SHV-32, TEM-1, CTX-M-15, OXA-48 | |
| PSA 1681d | CAIRD | >512 | 8 | OXA-486, PDC-8, OXA-10, CTX-M-2 | |
CAIRD, Center for Anti-Infective Research and Development; EC, E. coli; ECL, Enterobacter cloacae; KP, K. pneumoniae; PSA, P. aeruginosa; OSBL, original-spectrum β-lactamase.
PBP3 characterized by a 4-amino-acid (YRIK) insertion after position 333 and an A413V substitution.
G137D substitution in OmpC known to be present.
Mutation in OmpK35 porin known to be present.
MICs were previously reported.11
Molecular mechanisms of β-lactam resistance listed as posted on the FDA-CDC Antimicrobial Resistance Isolate Bank website at the time of study execution.