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Model of basal PDGFβR-EGFR heterodimer formation and signal transduction. PDGFβR and EGFR form a receptor complex (heterodimer) under basal cell conditions. The formation of the receptor complex may provide a scaffold for other molecules required for the transactivation. The interaction between the two receptors is regulated by ROS and Src family kinases. Note that we believe that the PDGFR dimers are physically closer than the EGFR dimers in three dimensions.
