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. 2023 Feb 16;17:1120086. doi: 10.3389/fnins.2023.1120086

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Copyright © 2023 Haukedal, Corsi, Gadekar, Doncheva, Kedia, de Haan, Chandrasekaran, Jensen, Schiønning, Vallin, Marlet, Poon, Pires, Agha, Wandall, Cirera, Simonsen, Nielsen, Nielsen, Hyttel, Muddashetty, Aldana, Gorodkin, Nair, Meyer, Larsen and Freude.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Golgi fragmentation is an early event in AD pathogenesis, triggered by Aβ42 peptides. (A) Quantitative assessment of MitoTracker™, mean area of distribution, in five-week L150P and A79V hiPSC derived neurons. (B) Quantitative assessment of cis- and trans-Golgi surface area in five-week L150P and A79V hiPSC derived neurons. (C) Quantitative assessment of cis- and trans-Golgi surface area in isogenic controls, following a 24-hour Aβ treatment. Results are displayed as mean ± standard error of the mean (SEM) from three replicates. Significance levels are indicated by *p < 0.05, ^***p < 0.001, and ^****p < 0.0001.