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. 2023 Feb 16;14:1137604. doi: 10.3389/fendo.2023.1137604

Figure 2.

Figure 2

Binding sites of allosteric modulators in Class A GPCRs. (A) Interactions of Cmpd-6FA (orange, sticks) with TM2, TM3, TM4, and ICL2 of β2AR (gray, cartoon) (PDB ID: 6N48). (B) Interactions of LY3154207 (pink, sticks) with TM2, TM3, TM4, and ICL2 of DRD1 (gray, cartoon) (PDB ID: 7CKZ). (C) Interactions of Cmpd-15PA (purple, sticks) with TM1, TM2, TM6, TM7, H8 and ICL1 of β2AR (gray, cartoon) (PDB ID: 5X7D). (D) Interactions of ZCZ011 (blue, sticks) with TM2, TM3 and TM4 of CB1R (gray, cartoon) (PDB ID: 7WV9). (E) Interactions of ORG27569 (deep blue, sticks) with TM2, TM3 and TM4 of CB1R (gray, cartoon) (PDB ID: 6KQI). (F) Interactions of MIPS521 (magentas, sticks) with TM6 and TM7 of A1R (gray, cartoon) (PDB ID: 7LD3). (G) Interactions of LY2116920 (yellow, sticks) with extracellular region of M2R (gray, cartoon) (PDB ID: 4MQT). (H) Interactions of DCA (wheat, sticks) with extracellular region of GPBAR (gray, cartoon) (PDB ID: 7CFM). (I) Interactions of cholesterol (green, sticks) with TM1 and TM7 of 5-HT1A (gray, cartoon) (PDB ID: 7E2Y).