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. 2023 Feb 16;14:1137604. doi: 10.3389/fendo.2023.1137604

Figure 5.

Figure 5

Binding Sites of allosteric modulators in Class C GPCRs. (A) Close view of binding sites of positive allosteric modulator BHFF (orange, sticks) in GABAB (dark cyan and light salmon, cartoon) (PDB ID: 7EB2). (B) Close view of binding sites of positive allosteric modulator cinacalcet (magentas, sticks) in CaSR (cornflower blue and medium aquamarine, cartoon) (PDB ID: 7M3F). (C) Close view of binding sites of negative allosteric modulator NPS-2143 (medium purple, sticks) in CaSR (cornflower blue and medium aquamarine, cartoon) (PDB ID: 7M3J).