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. 2023 Feb 16;17:1137893. doi: 10.3389/fnins.2023.1137893

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Copyright © 2023 Pan, Dutta, Lu and Bellen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The sphingolipid metabolism network. The biochemical reactions are grouped by the organelles in which they occur. The substrates and products are indicated in three colors depending on their presence in human and flies: black (both human and fly), green (human) and magenta (fly). The genes encoding the enzymes are also indicated in colors: blue (human) and red (fly). Asterisks indicate predicted orthologs in flies. Cer, ceramide; dhCer, dihydroceramide; C1P, ceramide-1-phosphate; GalCer, galactosylceramide; GlcCer, glucosylceramide; LacCer, lactosylceramide; MacCer, mannosyl glucosylceramide; PE, phosphoethanolamine; CPE, ceramide phosphoethanolamine; SM, sphingomyelin; Sph, sphingosine; dhSph, dihydrosphingosine; S1P, sphingosine-1-phosphate; GSL, glycosphingolipid.