Figure 5.

Compound 9a bound to dimeric NAMPT (PDB: 7Q8T). One chain is colored in blue the other in grey. The upper insert shows detailed interaction of 9a (pink) with surrounding residues as dashed black lines. Bridging water molecules are shown as red spheres. The bottom right insert shows the PRPP (teal) and nicotinamide mimetic (benzamide, BA, yellow) bound structure of BeF₃-His247 (PDB: 3DKL). Magnesium ions are coloured in green. The orientation is the same as in the upper panel. The conformation change of F193 and Y18 is indicated as a black outline. Bottom right shows the observed electron density of the ligand contoured at 1 σ.