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Effects of compounds 6 and 10 on NMN production in the biochemical NAMPT assay; (A) Dose response data. All data is from a minimum of three independent replicates conducted in triplicate and is shown as mean ± SEM (B) Comparison of effects of 6 (n = 21) and 10 (n = 9) at 10 μmol/L vs DMSO control (n = 81). Significant differences (from DMSO vehicle) are denoted by ∗∗P < 0.01 and ∗∗∗∗P < 0.0001.
