Table 1.

The comparison of PDC and ADC.

Property	PDC	ADC
Molecular weight	The weight of the molecule (2–20 kDa) is small, which makes it easier to penetrate the tumor stroma and enter the tumor cells	Large molecular weight (∼160 kDa) limits passive transport through epithelial cell membranes
Pharmacokinetic	Rapidly eliminated by the kidneys, making it less toxic to the bone marrow and liver	Non-specific uptake by the liver and reticuloendothelial system results in dose-limiting toxicity to the liver and bone marrow
Cost	It can be expressed in situ or chemically synthesized for simple production and easy scale-up	Relatively difficult to manufacture and costly to produce and qualify
Cytotoxic payload	Targeted formulations can be coupled with a variety of clinically proven cytotoxic molecules such as adriamycin, paclitaxel, camptothecin, cisplatin, and so on	Cytotoxic molecules are limited to a very few highly toxic candidates such as MMAE (monomethyl auristatin E), and DM-1 (mertansine)