Table 5.

Management of infections at specific sites

Infection site	Treatment
Skin and soft tissues	Provide effective wound care (e.g., eradication of necrotic tissue) Perform biopsy of skin lesions for histology and culture Administer empiric antibiotics administered to the wound Refer to the principal treatment of L-CRS for high-risk patients with severe infection caused by L-CRS
Urinary system	Monitor routine urine Replace urinary catheters regularly Collect microbiological samples If the patient develops infection-associated symptoms, initiate empiric antibiotic treatment according to local protocols
Intravenous catheter	Perform blood cultures for patients suspected of having CRBSI before administration of antimicrobial therapy Remove the catheter from patients with persistent hemodynamic instability or severe sepsis as soon as possible After organism and antibiotic sensitivities have been identified, the antibiotic regimen should be tailored on the basis of culture results
Serosal cavity catheter	Perform routine maintenance measures to prevent infection include daily disinfection of the exit site If the patient develops infection-associated symptoms, administer anti-infection treatment

L-CRS, local cytokine-release syndrome; CRBSI, catheter-associated bloodstream infections.