Table 1. Cohort Characteristics.
| Characteristic | No. (%) | P valuea | ||
|---|---|---|---|---|
| Known CAD (n = 449) | No known CAD (n = 981) | Total (N = 1430) | ||
| Age, mean (SD), y | 62.3 (11.9) | 55.4 (12.6) | 57.6 (12.8) | <.001 |
| Sex | ||||
| Male | 297 (66.2) | 478 (48.7) | 775 (54.2) | <.001 |
| Female | 152 (33.9) | 503 (51.3) | 655 (45.8) | |
| Race and ethnicity | ||||
| American Indian/Alaska Native | 7 (1.6) | 16 (1.6) | 23 (1.6) | <.001 |
| Asian | 0 | 12 (1.2) | 12 (0.8) | |
| Black or African American | 132 (29.4) | 392 (40.0) | 524 (36.6) | |
| Hispanic or Latino | 16 (3.6) | 41 (4.2) | 57 (4.0) | |
| Native Hawaiian | 1 (0.2) | 1 (0.1) | 2 (0.1) | |
| White | 293 (65.3) | 533 (54.3) | 826 (57.8) | |
| Not Hispanic or Latino | 430 (95.8) | 929 (94.7) | 1359 (95.0) | |
| Otherb | 16 (3.6) | 27 (2.8) | 43 (3.0) | |
| Unknown | 3 (0.7) | 11 (1.1) | 14 (1.0) | |
| Risk factors | ||||
| Current or history of smoking | 282 (62.8) | 509 (51.9) | 791 (55.3) | <.001 |
| Hypertension | 380 (84.6) | 571 (58.5) | 954 (66.7) | <.001 |
| Hyperlipidemia | 322 (71.7) | 361 (36.8) | 683 (47.8) | <.001 |
| Diabetes | 189 (42.1) | 231 (23.6) | 420 (29.4) | <.001 |
| Family history of coronary disease | 253 (56.4) | 408 (41.6) | 661 (46.2) | <.001 |
| BMI >30 | 237 (52.8) | 511 (52.1) | 748 (52.3) | .81 |
| Prior cerebrovascular accident | 93 (20.7) | 61 (6.2) | 154 (10.8) | <.001 |
| Prior peripheral vascular disease | 49 (10.9) | 40 (4.1) | 89 (6.2) | <.001 |
| Prior end-stage kidney disease | 36 (8.0) | 35 (3.6) | 71 (5.0) | <.001 |
| Chest pain onset, hours from arrival | ||||
| ≤3 | 153 (34.4) | 353 (36.0) | 505 (35.5) | .44 |
| >3 | 292 (65.6) | 625 (64.0) | 917 (65.5) | |
| ECG at arrival | <.001 | |||
| Ischemic | 42 (9.4) | 46 (4.7) | 88 (6.2) | |
| Nonischemic | 407 (90.7) | 935 (95.3) | 1342 (93.9) | |
| Initial study hs-cTnT sample, median (IQR), ng/L | 15 (8-35) | 7 (4-16) | 9.0 (5-21) | <.001 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CAD, coronary artery disease; ECG, electrocardiogram; hs-cTnT, high-sensitivity troponin T.
a
Categorical variables were compared between the known CAD and no known CAD groups using χ2 or Fisher exact test. The Wilcoxon rank sum test was used to compare age and hs-cTnT values.
b
Other included patients who did not identify with any of the specified races.