Table 1.

Discovered genes/enzymes for producing desired chemicals/degrading targeted pollutants.

Desired chemicals/Targeted pollutants		Pathway Genes/Enzymes discovered	Origin	Omics tools	Reference
Desired chemicals	ibogaine	ibogamine 10-hydroxylase, oribogaine-10-O-methyltransferase	Tabernanthe iboga	genomics/transcriptomics	[14]
	ferruginol	CYP76AH1	Salvia miltiorrhiza	transcriptomics	[15]
	O-glc- echinocystic acid	CYP716Y1	Bupleurum falcatum	transcriptomics	[16]
	cucurbitacin B and E	Cm180, CmBi, CmACT, Cm890, CmBt, Cl180, ClBi, ClACT, Cl890A, Cl890B, ClBt	Cucumis melo L, Citrullus lanatus	genomics/transcriptomics	[17]
	wogonin	O-methyltransferase (PFOMT5)	Scutellaria baicalensis Georgi	genomics	[18]
	saponins	oxidosqualene cyclases, CYP450s, UDP-glucuronosyltransferases	Maesa lanceolate, Chenopodium quinoa	transcriptomics	[19]
	olivetolic acid	olivetolic acid cyclase	Cannabis flowers	transcriptomics	[20]
Targeted pollutants	PET	a PET hydrolytic enzyme	Actinobacteria	metagenomics	[21]
	PU	gene sequences similar to PU hydrolytic enzyme	Landfill microbial community	metagenomics	[22]
	synthetic polyesters: PLA, PCL, PBSA	synthetic polyesters hydrolytic enzyme belonging to new esterase families	Environmental microbial community	metagenomics	[23]
	PCL, PET	a novel thermostable cutinase homologue, leaf and branch compost cutinase	Microbial community of a leaf-branch compost with copious natural plant-derived polymers	metagenomics	[24]
	poly DEGA	esterases capable of hydrolyzing poly DEGA	Moss-associated microorganisms.	metagenomics	[25]
	PBAT	esterases capable of hydrolyzing synthetic copolyester PBAT	Soil compost microorganisms	metagenomics	[25]
	PBAT	a novel PBAT degrading polyesterase- PpEst	Pseudomonas pseudoalcaligenes and Knufia chersoneso	proteomics	[26]
	PHB	a PHB depolymerase ALC24_4107	Alcanivorax sp. 24	proteomics	[27]