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. 2023 Mar 2;20(4):351–364. doi: 10.1038/s41423-023-00985-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Monocytes enhance the cytokine release of SARS-CoV-2-S CAR-T cells. A THP1, S-293T, and SARS-CoV-2-S CAR-T cells were mixed at the indicated ratios for three days before measuring the secretion of IFNγ and IL6 (mean ± s.e.m, ***P < 0.001). Data presented are the mean (± s.e.m) from three repeats. B Cells as described in A were subjected to measurement of the secretion of multiple cytokines by a multiplex bead array (mean ± s.e.m). C The violin plot shows the expression of IL8 (CXCL8) in the PBMCs of COVID-19 patients and healthy controls (***P < 0.001)