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. 2023 Mar 2;20(4):351–364. doi: 10.1038/s41423-023-00985-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as effective treatments for SARS-CoV-2-infected Syrian hamsters. We demonstrated the feasibility of producing SARS-CoV-2-S CAR-T cells that have immunological profiles similar to those of T cells from COVID-19 patients in the presence of the S protein. This CAR-T-cell model can be used to screen drugs to suppress SARS-CoV-2-induced cytokine release. Among the drugs screened, felodipine, fasudil, imatinib, and caspofungin are effective in protecting against SARS-CoV-2-induced lethal inflammation in Syrian hamsters