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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: J Expo Sci Environ Epidemiol. 2022 Aug 17;32(6):833–846. doi: 10.1038/s41370-022-00459-0

Fig. 2. Network representation of the parent-metabolite mapping for all NHANES metabolites.

Fig. 2

Parent chemicals were identified using the NHANES reports and text mining of PubMed abstracts based on metabolite synonyms and keywords such as “metabolism” or “metabolite”. Nodes are either exclusively a parent chemical (red), exclusively a metabolite (green), or a chemical that was directly measured in urine (blue). For chemicals in this latter set, they are chemicals for which we wished to report an exposure inference and could be a “metabolite” according to NHANES but also have known metabolites (for example, about a dozen of these are metals). Links (edges) are directed in the direction of metabolism (in other words, parent -> metabolite). Denser areas of the graph are annotated by chemical class, which was also obtained from the NHANES reports.