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. 2022 Jun 18;13(2):739–753. doi: 10.1016/j.apsb.2022.06.011

Figure 7.

Figure 7

Treatment of 326E decreases atherosclerosis in ApoE−/− mice. (A)–(B) Male 6–8 weeks ApoE−/− mice were induced by Western diet for 23–24 weeks. During the inducement, mice were received 326E or BA treatment once daily (n = 10). Western diet (normal chow supplemented with 0.2% cholesterol, w/w). Cholesterol levels (A) and triglycerides levels (B) in liver after 24 weeks treatment (n = 10); (C)–(D) Representative photographs of aortas from different groups after 24 weeks treatment (C); the quantifications (D) of the lesion areas in C (n = 10); (E)–(F) Representative H&E staining of cross-sections of aortic roots in different groups after 24 weeks treatment (E); the quantifications (F) of the lesion areas in E (n = 8–10); (G) Plasma contents of hsCRP in the indicated groups after 24 weeks treatment (n = 10); (H)–(L) Quantitative mRNA expression of Cd68, F4/80, Il-1β, Abcg5, Abcg8 in the liver after 326E and BA treatment. Data are mean ± SEM; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 compared to Veh. #P < 0.05, ##P < 0.01, ###P < 0.001 compared to indicated group. ns, not significant.