Table III:
Parent rating measures of executive functions and social-emotional functioning in individuals with Noonan syndrome and their unaffected siblings
| Measure | Noonan syndrome (n=32) | Unaffected siblings (n=16) | Mean difference (95% CI) | ||
|---|---|---|---|---|---|
| Mean (SD) | Clinically elevated (T-score ≥65) (%) | Mean (SD) | Clinically elevated (T-score ≥65) (%) | ||
| Executive Functioning (BRIEF) | |||||
| Inhibition | 57.0 (14.4) | 28 | 46.4 (12.3) | 6 | 10.6 (2.1 to 19.1) |
| Attention Shift | 54.0 (14.4) | 19 | 45.5 (9.4) | 6 | 8.5 (0.5 to 16.5) |
| Emotional Control | 54.3 (14.3) | 25 | 48.8 (14.6) | 13 | 5.4 (–3.4 to 14.3) |
| Initiation | 56.3 (13.7) | 34 | 48.8 (11.4) | 6 | 7.4 (–0.6 to 15.4) |
| Working Memory | 59.7 (13.6) | 34 | 46.8 (12.7) | 13 | 12.8 (4.6 to 21.0) |
| Plan/Organize | 57.2 (12.6) | 38 | 46.8 (12.2) | 13 | 10.4 (2.7 to 18.1) |
| Organization of Materials | 53.4 (12.2) | 25 | 49.1 (9.6) | 6 | 4.3 (–2.8 to 11.3) |
| Self-Monitor | 58.0 (13.6) | 38 | 46.2 (11.5) | 13 | 11.8 (3.8 to 19.8) |
| Social-Emotional Functioning (CBCL) | |||||
| Anxious/Depressed | 57.1 (10.1) | 16 | 58.9 (10.5) | 25 | −1.9 (–8.2 to 4.5) |
| Withdrawn/Depressed | 55.5 (8.8) | 13 | 56.6 (8.7) | 13% | −1.1 (–6.5 to 4.3) |
| Somatic Complaints | 60.6 (9.8) | 31 | 54.8 (7.9) | 13% | 5.8 (0.1 to 11.5) |
| Social Problems | 61.8 (8.2) | 38 | 54.9 (7.7) | 13% | 6.9 (2.0 to 11.9) |
| Thought Problems | 58.0 (8.7) | 22 | 54.2 (6.3) | 13% | 3.8 (–1.1 to 8.7) |
| Attention Problems | 63.3 (11.5) | 38 | 53.1 (7.4) | 6% | 10.2 (3.8 to 16.6) |
| Rule-Breaking Behavior | 54.3 (5.7) | 3 | 52.4 (5.2) | 6% | 1.9 (–1.6 to 5.3) |
| Aggressive Behavior | 56.6 (8.4) | 16 | 55.0 (9.5) | 13% | 1.6 (–3.9 to 7.0) |