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. Author manuscript; available in PMC: 2023 Mar 2.
Published in final edited form as: Biomed Pharmacother. 2020 Oct 3;132:110831. doi: 10.1016/j.biopha.2020.110831

Fig. 1. Fracture induces an early increase in intestinal permeability.

Fig. 1.

(A) Radiographs of a representative fractured femur immediately after fracture (Day 0) and throughout healing. (B) Plasma FITC-Dextran concentrations were significantly higher at day 3 and 7 post-fracture compared pre-fracture levels, with return to pre- fracture levels by day 10 (n = 6). Two-tailed paired Student’s t-test, *P < 0.05 vs prior to fracture (Fx) control. (C) Fracture upregulates gene expression of tight junction-associated proteins and Muc2 within the small intestines (n = 4). Significance determine with one-way ANOVA followed by Tukey’s multiple comparisons test. Data not sharing a common letter are significantly different at P < 0.05. Data represent mean ± SD.