FIGURE 10.

Schematic representation of the locus of enterocyte effacement (LEE) regulatory network. (A–H) Represent the primary regulatory circuits controlling LEE gene expression, as described in detail in the discussion. Green and red dashed lines indicate positive and negative regulatory pathways; black arrows indicate protein interactions. Thick arrows show a simplified representation of the seven operons previously reviewed in detail (Gaytan et al., 2016). Single genes are not illustrated. The first gene of the polycistronic LEE1 operon encodes Ler, while the bicistronic LEE7 operon codes for GrlR and GrlA. The light blue box represents several other global, ancestral and pathotype-specific regulators that modulate LEE gene expression, mainly by acting, but not exclusively, on Ler expression. Other colleagues have extensively and elegantly reviewed the regulatory elements known to modulate the regulation of the LEE (Furniss and Clements, 2018; Platenkamp and Mellies, 2018; Turner et al., 2019; Serapio-Palacios and Finlay, 2020). Created with BioRender.com.