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. 2023 Mar 1;25:23. doi: 10.1186/s13058-023-01621-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Distinct basal gene expression signature in tumors with lower ER. A Stratification of ER-positive breast tumor cases from TCGA into ERα low and ERα high groups, based on ERα expression. B Boxplots comparing the distribution of basal signature gene expression in the ERα low and ERα high groups. C Heatmap with supervised clustering of the ER-positive tumors highlighting higher basal signature gene expression in the ERα low group. D Stratification of ER-positive breast tumor cases from TCGA into ESR1 low and ESR1 high groups, based on ESR1 expression. E Boxplots comparing distribution of basal signature gene expression in the ESR1 low and ESR1 high groups. F Heatmap with supervised clustering of the ER-positive tumors highlighting higher basal signature gene expression in the ESR1 low group