Table 1.
Demographics
| MRI sample, N = 151 | Total N = 66 | PET sample | ||||
|---|---|---|---|---|---|---|
| PiB-negative, N = 34 | PiB-positive, N = 32 | Effect size | p value (PiB+ vs. PiB–) | |||
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||
| Sex = male (%) | 62 (41.1) | 29 (43.9) | 13 (38.2) | 16 (50.0) | V = 0.09 | 0.475 |
| Age (y) | 76.09 (5.60) | 78.36 (5.29) | 79.74 (6.06) | 76.91 (3.90) | d = 0.55 | 0.029 |
| APOE ε4+ (n [%]) | 43/149 (29%) | 20/66 (30%) | 3/34 (8.8) | 17/32 (53.1) | V = 0.45 | <0.001 |
| Education (y) | 16.79 (1.92) | 16.83 (1.78) | 17.15 (1.62) | 16.50 (1.90) | d = 0.37 | 0.14 |
| GDS | 3.32 (2.78) | 3.26 (3.15) | 3.65 (3.42) | 2.84 (2.83) | d = 0.26 | 0.304 |
| MMSE | 28.69 (1.35) | 28.73 (1.25) | 29.00 (0.89) | 28.44 (1.50) | d = 0.46 | 0.067 |
| CVLT LDFR | 10.42 (3.27) | 10.09 (3.60) | 10.56 (3.72) | 9.59 (3.46) | d = 0.27 | 0.28 |
| VRII recall | 53.52 (21.84) | 53.21 (20.02) | 52.74 (21.35) | 53.72 (18.84) | d = −0.05 | 0.844 |
| Digit span | 16.11 (3.81) | 15.56 (3.93) | 16.24 (4.40) | 14.84 (3.29) | d = 0.36 | 0.152 |
| Stroop correct in 60 s | 46.49 (11.43) | 47.88 (10.06) | 48.68 (10.73) | 47.03 (9.39) | d = 0.16 | 0.511 |
| Verbal fluency | 46.04 (12.28) | 47.55 (11.27) | 49.38 (11.09) | 45.59 (11.31) | d = 0.34 | 0.174 |
| Category fluency | 34.05 (8.40) | 33.09 (8.05) | 33.71 (8.45) | 32.44 (7.69) | d = 0.16 | 0.527 |
| COG-MRI interval (d) | 89.84 (44.10) | |||||
| COG-FTP interval (d) | 87.17 (48.35) | 84.88 (48.02) | 89.59 (49.34) | d = −0.10 | 0.696 | |
| MRI-FTP interval (d)* | 1030.94 (1020.37) | 1016.74 (1083.98) | 1046.03 (965.29) | d = −0.03 | 0.908 | |
| PiB-positive (%) | 32 (48.5) | |||||
Key: APOE, apolipoprotein E; GDS, geriatric depression scale; MMSE, mini-mental state examination; MRI, magnetic resonance imaging; CVLT LDFR, California verbal learning test long delay free recall; VRII, visual reproduction long delay; FTP, Flortaucipir; V, Cramér’s V; d, Cohen’s d.
*
Time between MRI obtained for cortical thickness and FTP PET scan.