Sachdeva 2015.

Study characteristics
Methods	Single‐centre, randomised controlled trial conducted in India
Participants	Inclusion criteria: (quote:) "Healthy" infants > 34 weeks' gestation; hyperbilirubinaemia requiring phototherapy for a minimum of 8 hours Exclusion criteria: (quote:) "Major congenital malformations"; Apgar score < 4 at 5 minutes; onset of jaundice within first 24 hours of life, total serum bilirubin > 18 mg/dL at the time of admission; rise of bilirubin > 0.5 mg/dL/h in the initial 8 hours of starting phototherapy; haemolytic cause of jaundice (positive Coombs’ test, evidence of haemolysis on peripheral smear, reticulocyte count > 6%); total serum bilirubin in exchange range at the time of admission; requiring NICU admission for any reason other than jaundice; direct bilirubin > 15% of total bilirubin; direct bilirubin > 1.5 mg/dL
Interventions	Total N = 75 Group 1 (n = 39): continuous phototherapy (phototherapy interrupted for feeding) Group 2 (n = 36): intermittent phototherapy (12 hours on, 12 hours off) Phototherapy was continued until 2 serum bilirubin values measured 12 hours apart < 13 mg/dL
Outcomes	Primary outcome Rate of fall of bilirubin (difference between maximum bilirubin after enrolment and bilirubin at end of phototherapy divided by the duration of phototherapy (actual duration of exposure)) Secondary outcomes Duration of phototherapy Failure of phototherapy Incidence of rebound phototherapy (2nd episode of hyperbilirubinaemia requiring phototherapy) Duration of hospitalisation
Notes	CTRI registration number: CTRI/2014/05/004584
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "the infant was randomized either into intermittent (IPT) or continuous (CPT) group using a computer‐generated random number sequence with 1:1 allocation ratio".
Allocation concealment (selection bias)	Low risk	Quote: "The site investigator allocated the group by opening serially numbered, opaque, sealed, identical envelopes containing the treatment group allocation".
Blinding (performance bias and detection bias) All outcomes	Low risk	Unblinded study with objective outcome measures
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Unblinded study with objective outcome measures
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Unblinded study with objective outcome measures
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete outcome data provided for all infants
Selective reporting (reporting bias)	Unclear risk	Trial registered retrospectively
Other bias	Low risk	No other potential sources of bias were identified