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. 2023 Jan 19;64(1):74–80. doi: 10.4103/singaporemedj.SMJ-2021-300

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Copyright: © 2023 Singapore Medical Journal

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Tc-99m-PYP scintigraphy images of a patient with transthyretin amyloid cardiomyopathy. Delayed planar and single photon emission chest CT images up to 3 hours were obtained following intravenous administration of Tc-99m-PYP. (a) There was diffuse, moderately intense radiotracer uptake of the myocardium, in particular the left ventricular wall. Overall, the uptake intensity was slightly higher than that of the adjacent ribs (indicating grade 3 myocardial PYP-uptake). (b) The calculated heart uptake: contralateral chest uptake ratio at 1-hour post-radiotracer administration was approximately 2.34 (>1.5), which was highly suggestive of transthyretin cardiac amyloidosis.