Figure 1:

Global amyloid deposition in Centiloids plotted against CSF levels of Aβ42/Aβ40 in A) ADAD MCs (n = 219) and B) participants with DS (n = 32). Plotted data points were categorized by participants’ cognitive status as measured by CDR in MCs and consensus diagnosis in DS. Correlation analysis between CSF Aβ42/Aβ40 and Centiloids was performed using Spearman’s rank correlation test. Abbreviations: Aβ = amyloid-beta; CDR = clinical diagnosis rating; CSF = cerebrospinal fluid; DS = Down syndrome; MC = mutation-carrier; MCI = mild cognitive impairment; PET = positron emission tomography