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Regional PiB SUVRs at A) EYO = −20, B) EYO = −10, C) EYO = 0, and D) EYO = 10 in autosomal dominant AD MCs, participants with DS, and the significant difference between MC and DS SUVRs using a 99% confidence interval to adjust for multiple comparisons. Abbreviations: AD = Alzheimer’s disease; EYO = estimated years to symptom onset; DS = Down syndrome; MC = autosomal dominant AD mutation carrier; SUVR = standard uptake value ratio
