Table 2. Top associations between autoantibodies to citrullinated and native antigens and incident RA-ILD in 84 BRASS RA-ILD cases and 233 RA-noILD controls.
| Targeted antigen* | Adjusted** OR (95% CI) | FDR p-value |
|---|---|---|
| Citrullinated | ||
| H4 33–48 cit 39 (IgA2) | 0·08 (0·03,0·22) | <0·001 |
| H2A/a-2 1–20 cit (IgA2) | 4·03 (2·03,8·00) | 0·003 |
| Filaggrin 48–65 cit2 cyclic (IgG) | 3·47 (1·71,7·01) | 0·014 |
| FibrinogenB 36–52 cit (IgA2) | 0·37 (0·16,0·86) | 0·397 |
| Clusterin 231–250 cit cyclic (IgG) | 1·27 (1·03,1·56) | 0·397 |
| H4 33–48 cit 39 40 (IgG) | 1·25 (1·02,1·53) | 0·397 |
| Filaggrin 48–65 cit2 cyclic (IgA2) | 5.04 (1·10,23·1) | 0·419 |
| H2A/a 1–20 cit cyclic (IgA2) | 1·60 (1·00,2·57) | 0·455 |
| Fibronectin cit 1035 1036 (IgG) | 1·22 (0·99,1·50) | 0·455 |
| Filaggrin 48–65 cit2 cyclic (IgA1) | 1·87 (0·98,3·59) | 0·455 |
| Non-Citrullinated (Native) | ||
| H2A/a 1–20 cyclic (IgA2) | 5·52 (2·38,12·78) | 0·001 |
| H2A/a-2 1–20 (IgA2) | 4·60 (2·18,9·74) | 0·001 |
| Filaggrin 48–65 cyclic (IgG) | 2·53 (1·47,4·34) | 0·010 |
| H2A/a 1–20 cyclic (IgG) | 1·91 (1·18,3·10) | 0·088 |
| H2A/a-2 1–20 (IgG) | 1·86 (1·14,3·05) | 0·105 |
| tenascin C 1 (IgG) | 0·69 (0·50,0·95) | 0·148 |
| tenascin C 1 (IgA1) | 0·73 (0·54,0·98) | 0·195 |
| Vimentin 58–77 cyclic (IgG) | 1·51 (1·02,2·24) | 0·195 |
| tenascin C 1 (IgA2) | 0·50 (0·22,1·15) | 0·455 |
| Vimentin 58–77 cyclic (IgA2) | 1·75 (0·84,3·63) | 0·530 |
BMI = body mass index, BRASS = Brigham Rheumatoid Arthritis Sequential Study, CI = confidence interval, cit = citrullinated, CRP = C-reactive protein, DAS = disease activity score, bDMARD = biologic disease-modifying anti-rheumatic drug, FDR = false discovery rate, H = histone, Ig = immunoglobulin, ILD = interstitial lung disease, MDHAQ = multi-dimensional health assessment questionnaire, OR = odds ratio, RA = rheumatoid arthritis, RF = rheumatoid factor
Additional results are shown in Supplemental Tables 2 and 3.
Presented by level of significance within each category.
Per log-transformed unit. Bold values indicate FDR p<0.05 (and nominal p<0.001).
Adjusting for significant covariates including BMI, smoking pack-years, DAS28-CRP, MDHAQ, rheumatoid nodules, bDMARD use, methotrexate use, glucocorticoid use, and MUC5B genotype.