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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Lancet Rheumatol. 2023 Jan 24;5(2):e77–e87. doi: 10.1016/s2665-9913(22)00380-0

Table 4. Risk score for developing RA-ILD (with and without biomarkers).

Score Points
Variable* Without biomarkers With biomarkers
Smoking pack-years ≥30 1·9 2·3
DAS28-CRP ≥3.2 1·2 1·2
Current glucocorticoid use 1·0 1·2
BMI ≥30 kg/m2 0·4 0·8
Filaggrin 48–65 cit 2 cyclic (IgG), highest tertile 2·0
H4 33–48 cit 39 (IgA2), lowest tertile 1·9
H2A/a-2 1–20 (IgA2), highest tertile 1·8
MUC5B promoter variant present 0·1

BMI = body mass index, CI = confidence interval, CRP = C-reactive protein, Ig = immunoglobulin, ILD = interstitial lung disease, OR = odds ratio, RA = rheumatoid arthritis

*

Intended to be recorded as of time of calculation