Table 3.

Characterization of optimum APT-IE during 6 months of investigation at 25 ± 2 °C and 4 ± 2 °C (n = 3).

Characterization of APT-IE	0 time	Storage at 25 ± 2 °Cfor 6 months	Storage at 4 ± 2 °Cfor 6 months
Physical appearance	off-white to amber liquid(Good)	Dark yellow, Poor liquidity(Bad)	off-white to amber liquid(Good)
Particle size(nm)	82.83 ± 1.28	81.80 ± 1.43	82.09 ± 1.26#
PDI	0.243 ± 0.002	0.206 ± 0.002	0.205 ± 0.005#
pH	8.21 ± 0.07	7.24 ± 0.06*	8.18 ± 0.04#
The existence of drug crystal	NF(Not find)	NF	NF
Zeta potential(mv)	−59.00 ± 1.59	−55.04 ± 2.04	−56.50 ± 1.29#
Drug content(%)	98.44 ± 1.43	75.80 ± 2.15*	97.89 ± 1.75#
Osmotic pressure(mOsmol·kg–1)	301 ± 2.15	305 ± 1.80	299 ± 1.73#

^#Comparison 0 time, P > 0.05, not significant; ^*Comparison 0 time, P < 0.05, significant.