Table 4.

Pharmacokinetic parameters after intravenous administration of APT-IE and APT-SL to rats (n = 6).

Parameter	APT-IE	APT-SL
Cmax (μg·mL−1)	32.95 ± 5.09*	14.2 ± 4.12
AUC(0–∞) (h·μg·mL−1)	39.72 ± 3.17*	12.72 ± 2.42
MRT(0–t) (h)	2.72 ± 0.09*	2.05 ± 0.22
T1/2 (h)	4.14 ± 1.08	4.88 ± 1.87
Vd (L·kg−1)	1.76 ± 0.42*	6.49 ± 2.48
CL (L·h·kg−1)	0.30 ± 0.02*	0.94 ± 0.14

^*Compared APT-SL, P < 0.05, significant.