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. 2023 Mar 1;30(1):2181743. doi: 10.1080/10717544.2023.2181743

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — In vivo antitumor efficacy evaluation of PA, MnO₂ NPs and MnO₂@PA NPs oligomer in 143B tumor-bearing mice. A: The dosage frequency of therapeutics after tumor inoculation. Mice received 20 mg/kg of PA, MnO₂ NPs or MnO₂@PA NPs. B: The tumor growth curves after i.v. injection of PA, MnO₂ NPs, and MnO₂@PA NPs oligomer. The data were shown as mean ± SD, **p < .01 vs. PA group and MnO₂ NPs group. C: The excised tumor images with PA, MnO₂ NPs, or MnO₂@PA NPs oligomer treatment. D: The contents of manganese in excised tumor. The data were shown as mean ± SD, **p < .01 vs. control group. E: TUNEL detection and immunohistochemistry assay for Ki67 in tumor tissues, (scale bar: 50 μm).