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[Preprint]. 2023 Feb 27:2023.02.22.529576. [Version 2] doi: 10.1101/2023.02.22.529576

Figure 7. DOCK3 interacts with SORBS1 via binding to the SORBS1 SH3 domains.

Figure 7.

A. Schematic showing the SORBS1 deletion constructs indicating full length SORBS1, and deletion domains across each SH3 domain. B. The co-IP indicating the interaction and expression of each deletion construct in HEK293T cells. C. The co-IP of DOCK3-SORBS1 in human primary myoblasts. Immunoblot (DOCK3 rabbit polyclonal antibody) with the co-immunoprecipitation (SORBS1-FLAG; FLAG mouse monoclonal antibody) D. The co-IP of SORBS1 deletion constructs containing deletions of each of the SH3 domains in SORBS1 showing the requirements for each in binding to DOCK3.