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[Preprint]. 2023 Feb 24:rs.3.rs-2073736. [Version 1] doi: 10.21203/rs.3.rs-2073736/v1

Figure 3. Chromatin contact analysis of selected genome-wide significant variants identified on Chromosome 11.

Figure 3

Figure 3 shows the chromatin contact between the causal variants within the signals (Panel A: FADS region and Panel B: POLD4region) located in open chromatin defined by ATAC-seq with gene promoters defined by Promoter Capture C in multiple metabolic-relevant cell types, including: human mesenchymal stem cells (hMSC), which were also differentiated in vitro to adipocytes (hMSC_Adipocytes), induced pluripotent stem cell derived Hepatocytes (iPSC_Hepatocytes), embryonic stem cell derived Hypothalamic Neurons (hESC_HypothalamicNeurons), Enteroids, and HepG2s.