Table 2.
Genome-wide significant signals (Credible sets) for PUFAs in CHARGE Hispanic Americans.
| Variants (Chr:Pos:EFF:OTH) |
EAF | Zscore | Pvalue | Cluster | #Of SNP |
Novel/ Known |
Nearest Gene |
|
|---|---|---|---|---|---|---|---|---|
| AA | rs102274 (11:61557826:C:T) | 0.506 | −24.26 | 5.1E-130 | 1 | 7 | Known | TMEM258 |
| rs142068305 (11:67065755:T:G) | 0.196 | −7.06 | 1.63E-12 | 2 | 1 | Novel | ANKRD13D | |
| rs28364240 (11:67120530:G:C) | 0.204 | −7.04 | 1.88E-12 | 3 | 1 | Novel | POLD4 | |
| rs2668898 (11:61725498:G/A) | 0.402 | −5.83 | 5.32E-09 | 4 | 1 | Known | BEST1 | |
| rs180792704 (11:67325239:C:G) | 0.199 | −7.56 | 3.81E-14 | 5 | 1 | Novel | NA | |
| rs198434 (11:61483417:A:G) | 0.710 | −8.97 | 2.80E-19 | 6 | 1 | Known | DAGLA | |
| rs518804 (11:57494487:C:A) | 0.420 | −7.73 | 1.01E-14 | 7 | 1 | Novel | TMX2 | |
| rs3177514 (11:66130358:G:T) | 0.699 | −5.60 | 2.06E-08 | 8 | 1 | Novel | SLC29A2 | |
| ALA | rs174562 (11:61585144:G:A) | 0.503 | 7.84 | 4.30E-15 | 1 | 23 | Known | FADS1 |
| DGLA | rs174538 (11:61560081:A:G) | 0.488 | 14.70 | 6.03E-49 | 1 | 1 | Known | TMEM258 |
| rs174585 (11:61611694:A:G) | 0.274 | 9.82 | 8.72E-23 | 2 | 1 | Known | FADS2 | |
| rs198434 (11:61483417:A:G) | 0.710 | 6.27 | 3.57E-10 | 3 | 1 | Known | DAGLA | |
| rs198461 (11:61524366:C:A) | 0.363 | −5.95 | 2.54E-09 | 4 | 1 | Known | MYRF | |
| rs57112407 (15:78088914:T:C) | 0.255 | −5.86 | 4.46E-09 | NA | NA | Novel | LINGO1 | |
| rs4985155 (16:15129459:G:A) | 0.524 | −7.72 | 1.16E-14 | 1 | 25 | Known | PDXDC1 | |
| DPA | rs1535 (11:61597972:G:A) | 0.520 | −11.31 | 1.07E-29 | 1 | 18 | Known | FADS2 |
| rs198434 (11:61483417:A:G) | 0.710 | −6.26 | 3.67E-10 | 2 | 1 | Known | DAGLA | |
| EPA | rs102274 (11: 61557826:C:T) | 0.506 | −11.56 | 6.18E-31 | 1 | 17 | Known | TMEM258 |
| GLA | rs174576 (11: 61603510:A:C) | 0.546 | −7.73 | 1.07E-14 | 1 | 19 | Known | FADS2 |
| LA | rs174564 (11:61588305:G:A) | 0.520 | 15.11 | 1.23E-51 | 1 | 10 | Known | FADS2 |
| rs10751002 (11:63617634:G:T) | 0.664 | 6.06 | 1.36E-09 | 2 | 1 | Novel | MARK2 | |
| rs2668898 (11:61725498:G:A) | 0.402 | 5.54 | 2.99E-08 | 3 | 1 | Known | BEST1 | |
| rs28364240 (11:67120530:G:C) | 0.204 | 5.90 | 3.44E-09 | 4 | 1 | Novel | POLD4 | |
| rs11039018 (11:46909524:A:C) | 0.67 | −6.10 | 1.01E-09 | 5 | 1 | Novel | LRP4 | |
| rs518804 (11:57494487:C:A) | 0.420 | 6.03 | 1.62E-09 | 6 | 1 | Known | TMX2 |