Table 5.
Integrative analysis (Colocalization and PrediXcan) in the Hispanic Americans using multi-ancestry resources from MESA and GTEx.
| Colocalization Analysis | PrediXcan | |||
|---|---|---|---|---|
| MESA multi- ethnics eQTLs |
GTEx eQTLs |
MESA | GTEx | |
| AA | Chromosome 11 | |||
| MED19, TMEM258, PACS1, RAD9A | RPS4XP13, AP001462.6 | TMEM258, TMEM109, ZBTB3, TTC9C, FERMT3, MED19, POLD4, CLCF1, INCENP, MADD, SSH3, C11orf24, PRPF19, TBC1D10C, BANF1, CCDC86, NXF1, MS4A6E, CCS, COX8A, CCDC88B, ACP2, MAP4K2 | TMEM258, TMEM223, NXF1, INCENP, MUS81, C11orf84, MED19, MEN1, BBS1, NEAT1, DPP3, SSH3, ACP2, ASRGL1, RNASEH2C | |
| ALA | Chromosome 11 | |||
| TMEM258, MED19 | MED19, PGA5, TMEM258 | TMEM258, TMEM109 | TMEM258 | |
| DGLA | Chromosome 11 | |||
| TMEM258 | TMEM258, ZBTB3 | TMEM258, FADS1, FADS2 | ||
| Chromosome 16 | ||||
| PDXDC1 | RP11-426C22.5 | PDXDC1 | NPIPA2 | |
| DPA | Chromosome 11 | |||
| TMEM258, C11orf24, RAD9A | PGA5 | TMEM258, TMEM109 | TMEM258, SSH3, TMEM223 | |
| EPA | Chromosome 11 | |||
| TMEM258 | TPCN2 | TMEM258, FERMT3, TMEM109 | TMEM258, SSH3, TMEM223 | |
| GLA | Chromosome 11 | |||
| TMEM258 | MEN1 | TMEM258 | TMEM258 | |
| Chromosome 11 | ||||
| LA | MED19, CTTN, C11orf24, RAD9A | MED19, TPCN2, FADS1, RPS4XP13, AP001462.6 | TMEM258, TMEM109, FERMT3, ZBTB3, COX8A, MADD, POLD4, TBC1D10C, INCENP, TTC9C, MED19, CLCF1, SSH3, ACP2 | TMEM258, INCENP, SSH3, C11orf84, TMEM223, GIF, NXF1, MED19, MUS81, ACP2 |