Table 1.
Overview of the characteristics of the study population
| Women | Men | ||||||
|---|---|---|---|---|---|---|---|
| Mean / N | SD / % | N | Mean / N | SD / % | N | ||
| Characteristics | |||||||
| Study | FHS | 665 | 62.6 | 1062 | 1,088 | 67.5 | 1612 |
| InCHIANTI | 193 | 18.2 | 222 | 13.8 | |||
| BLSA | 204 | 19.2 | 302 | 18.7 | |||
| Age at sex hormone measurement | years | 66.5 | 9.8 | 1062 | 62.4 | 12.2 | 1612 |
| Age at DNA methylation | years | 70.6 | 8.9 | 1062 | 66.9 | 11.6 | 1612 |
| Time between visits among FHS | years | 6.6 | 0.6 | 665 | 6.6 | 0.7 | 1088 |
| Age of menopause | years | 48.6 | 6.0 | 991 | NA | ||
| Time since menopause at sex hormone measurements | years | 17.3 | 11.0 | 991 | NA | ||
| Smoking status at sex hormone measurements | never | 437 | 40.7 | 1075 | 485 | 29.9 | 1624 |
| Former/current | 638 | 59.3 | 1,139 | 70.1 | |||
| Packyears at sex hormone measurements among smokers | pack-years | 17.8 | 18.4 | 638 | 24.1 | 20.8 | 1139 |
| Alcohol intake | Drinks/weeks | 7.0 | 9.2 | 1015 | 19.4 | 24.2 | 1488 |
| BMI at sex hormone measurement | kg/m2 | 27.5 | 5.2 | 1073 | 28.3 | 4.4 | 1622 |
| Hormone levels | |||||||
| Total estrone | pg/ml | 32.2 | 20.9 | 634 | 50.6 | 17.7 | 1037 |
| Total estradiol | pg/ml | 11.0 | 19.6 | 984 | 23.9 | 10.1 | 1519 |
| SHBG | nmol/L | 83.3 | 49.4 | 832 | 61.7 | 31.5 | 1260 |
| Total testosterone | ng/dl | 35.4 | 28.0 | 1017 | 541.3 | 226.6 | 1533 |
| DHEAS | ug/dl | 86.2 | 71.4 | 192 | 143.1 | 115.6 | 221 |
| Bioavailable sex hormones | |||||||
| Bioavailable estrone | pg/ml | 1.0 | 0.7 | 633 | 1.8 | 0.6 | 1037 |
| Bioavailable estradiol | pg/ml | 0.2 | 0.3 | 812 | 0.5 | 0.2 | 1250 |
| Bioavailable testosterone | pg/ml | 4.0 | 3.0 | 829 | 82.7 | 35.0 | 1259 |
| Main outcome | |||||||
| Pheno AA | years | −0.7 | 6.4 | 1075 | 0.8 | 6.1 | 1624 |
| Grim AA | years | −1.6 | 4.0 | 1075 | 1.7 | 4.5 | 1624 |
| DNAm PAI1 | pg/ml | 19021 | 2862 | 1075 | 20865 | 3117 | 1624 |
| DNAm Leptin | pg/ml | 12026 | 2839 | 1075 | 4769 | 1648 | 1624 |
Abbreviations: N: Number; SD: Standard Deviation; years: years; NA: Not applicable; FHS: Framingham Heart Study; BLSA: Baltimore Longitudinal Study of Aging