Table 3.

Association between sex hormones and an aggregate outcome. We normalized each outcome first (mean zero; standard deviation one) followed by summarization of the four outcomes (Pheno AA, Grim AA, DNAm PAI1, and DNAm Leptin) into one aggregate. Associations were calculated using a linear mixed model adjusting for familial relationships.

	Men					Females
Exposure	Estimate	95%LL	95%UL	P-value	BH-P	Estimate	95%LL	95%UL	P-value	BH-P
E1	0.03	−0.01	0.06	0.17	0.25	0.00	−0.04	0.05	1.00	1.00
E2	−0.01	−0.04	0.02	0.42	0.50	0.03	−0.01	0.07	0.11	0.23
SHBG	−0.05	−0.08	−0.02	2E-03	4E-03	−0.08	−0.11	−0.04	9E-05	5E-04
TotT	−0.07	−0.10	−0.04	4E-06	3E-05	0.00	−0.04	0.03	0.96	1.00
TE ratio	−0.05	−0.08	−0.02	1E-03	4E-03	−0.04	−0.07	0.00	0.05	0.16
DHEAS	0.02	−0.05	0.09	0.59	0.59	0.03	−0.04	0.10	0.37	0.55