Table 2.

Likelihood ratio analysis of the maximum SpliceAI Δ score for non-canonical splice site variants using optimal cut-offs.

SpliceAI Δ score	Splice event - No		Splice event - Yes		LR	Low CI	High CI	Evidence strength^
	n	Proportion	n	Proportion
≤0.1	1962	0.87	72	0.15	0.17	0.14	0.21	Moderate evidence (non-spliceogenicity)
>0.1 and <0.2	175	0.08	38	0.08	1.00	0.71	1.39	Uninformative
≥0.2	109	0.05	381	0.78	15.99	13.23	19.32	Moderate evidence (spliceogenicity)

Abbreviation: CI, Confidence interval; LR, Likelihood ratio; n, number.

^{^}See Table S5 for criteria thresholds