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YYD inactivates EGFR-PI3K-AKT signaling in NSCLC cells. (a, b) Effects of YYD (0, 125, and 250 μg/ml) on the expression levels of p-EGFR, EGFR, p-PI3K, PI3K, p-AKT, and AKT were determined with western blot assays. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 versus the nontreated group.
