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[Preprint]. 2023 Feb 25:2023.02.24.529970. [Version 1] doi: 10.1101/2023.02.24.529970

Figure 4. Heterogeneity and evidence for metastasis in tumors from CAG-A3B animals.

Figure 4.

(A-B) Representative normal intestine with Peyer’s patch (arrow) and normal liver tissues, respectively, from CAG-A3B mice.

(C-D) Macroscopic pictures of a heterogeneous assortment lymphomas and hepatocellular carcinomas, respectively, from CAG-A3B mice.

(E) Representative image of a primary hepatocellular carcinoma that metastasized to the lung (HCC B from CAG-A3B #13 in panel D).

(F) H&E, anti-A3B, and anti-B220 IHC of lymphoma B from CAG-A3B #12. Inset boxes show the same tumors at 4x additional magnification.

(G) H&E and anti-A3B IHC of HCC from CAG-A3B #2. Inset boxes show the same tumors at 4x additional magnification.

(H) H&E and anti-A3B IHC staining of a primary hepatocellular carcinoma (top) and its metastatic dissemination to the lung (bottom) from CAG-A3B #13. Inset boxes show the same tumors at 4x additional magnification.

(I) H&E and anti-A3B IHC staining of a diffuse large B-cell lymphoma in the liver (left) and kidney (right). Inset boxes show the same tumors at 4x additional magnification.

See also Figures S5 and S6.