Table 4.

Examples of partial and weak antigens caused by aberrant RHCE alleles

Mechanism	Example	“Parent allele”	Mutation	Antigens lost	Antigens expressed
Gene conversion	E category II 89	cE	Ce-D(2–3)-ce
	${\overline{\overline{\text{R}}}}^{\text{N}}$ 90	Ce	RHCE-D(4)-CE	Rh46	Rh32
		Ce	RHCE-D(3 partial-4)-CE
	R 0 Har 31	ce *	RHCE-D(5)-CE		Rh33, Rh50
	CeVA 91	Ce	RHCE-D(5)-CE		Rh33, Rh50
Missense mutation (exofacial)	C X 92	Ce	A36T	MAR	CX
	C W 92	Ce	Q41R	MAR	CW
	RH:-26 93	ce	G96S	Rh26
	CeMA	Ce	R114W		(Har*)
	E cat V = EHK 28	cE	R154T	E epitopes
	ceRT 32	ce	R154T		D epitope 6
	E cat I 89	E	M167K	E epitopes
	E cat III 89	E	Q233E, M238V	E epitopes
Missense mutation (non-exofacial)	E cat IV 89	E	R201T	E epitopes ?
	VS 70	ce(W16C) †	L245V		VS
In-frame-deletion	e U 95		Del 229	Very weak e

^*RBC samples harboring this allele react with human serum Har. It is unknown whether the target antigen of this serum is identical to a known low-frequency antigen of the Rh blood group

^†ce(W16C) indicates ce allele encoding cysteine at codon 16.This allele is generally associated with a Dce haplotype⁶⁹ and encodes a weakened e antigen.⁹⁴ Most “African” RHCE alleles derive from this allele.