FIGURE 1.

Overview of study. The objectives of this study were to examine the continuous relationships of amyloid positron emission tomography (PET) with cerebrospinal fluid (CSF) and plasma amyloid beta (Aβ)42/Aβ40, and to determine whether these fluid biomarkers could be used to stage amyloidosis. We built a three‐layer neural network with dropout to predict amyloid PET standardized uptake value ratio (SUVR) using CSF and plasma Aβ42/Aβ40 (A). We evaluated the accuracy of these predictions (B), including across the range of amyloid PET SUVR values (C). We categorized individuals according to regional amyloid PET as described by Collij et al. ¹³ (D) and compared the stages to those predicted by CSF Aβ42/Aβ40.