TABLE 1.
Participant characteristics.
| Entire cohort | PET Amyloid Negative | PET Amyloid Positive | p | |
|---|---|---|---|---|
| N | 491 | 334 | 157 | |
| Age in years (mean ± SD) | 69.0 ± 8.8 | 67.1 ± 8.9 | 73.2 ± 6.8 | <0.001 |
| Gender, female n (%) | 270 (55%) | 194 (58%) | 76 (48%) | 0.06 |
| CDR | <0.001 | |||
| 0 | 427 (87%) | 316 (95%) | 111 (71%) | |
| 0.5 | 54 (11%) | 16 (5%) | 38 (26%) | |
| 1 | 10 (2%) | 2 (0.6%) | 8 (5%) | |
| APOE genotype, n (%) | <0.001 | |||
| ε2/ε2 | 1 (0.2%) | 1 (0.3%) | 0 (0%) | |
| ε2/ε3 | 51 (11%) | 48 (15%) | 3 (2%) | |
| ε2/ε4 | 15 (3%) | 9 (3%) | 6 (4%) | |
| ε3/ε3 | 248 (52%) | 197 (60%) | 54 (35%) | |
| ε3/ε4 | 138 (29%) | 67 (20%) | 71 (46%) | |
| ε4/ε4 | 28 (6%) | 7 (2%) | 21 (14%) | |
| Race, n (%) | 0.02 | |||
| White | 438 (89%) | 289 (87%) | 149 (95%) | |
| Black | 48 (10%) | 42 (13%) | 6 (4%) | |
| Other | 5 (1%) | 3 (0.9%) | 2 (1.2%) | |
| Years of education (mean ± SD) | 16.0 ± 2.6 | 16.2 ± 2.4 | 15.7 ± 2.8 | 0.09 |
| Years between amyloid PET and fluid biomarker collection a (mean ± SD) | −0.03 (0.57) | −0.04 (0.55) | −0.03 (0.61) | 0.835 |
| Mean cortical SUVR (mean ± SD) | 1.52 ± 0.79 | 1.06 ± 0.11 | 2.50 ± 0.73 | <0.001 |
| Mean cortical Centiloids (mean ± SD) | 20.94 ± 35.66 | 0.19 ± 4.84 | 64.97 ± 32.68 | <0.001 |
| CSF Aβ42/Aβ40 (mean ± SD) | 0.073 ± 0.023 | 0.086 ± 0.014 | 0.046 ± 0.011 | <0.001 |
| Plasma Aβ42/Aβ40 (mean ± SD) | 0.101 ± 0.009 | 0.104 ± 0.008 | 0.094 ± 0.007 | <0.001 |
a
Negative sign indicates that amyloid positron emission tomography (PET) imaging occurred after fluid biomarker collection.