Table 2.
Cox proportional hazard regression analyses of factors affecting lung transplant survival
| Variable | Univariate (unadjusted HR, 95% CI) | P value | Multivariate (aHR, 95% CI) All eras |
P value | Multivariate (aHR, 95% CI) 1987–2000 |
P value | Multivariate (aHR, 95% CI) 2001–2010 |
P value | Multivariate (aHR, 95% CI) 2011–2020 |
P value |
| Age at transplantation ≥50 | 1.76 (1.27 to 2.49) | 0.0010 | 2.36 (1.55 to 3.72) | 0.0001 | 8.01 (1.16 to 113.0) | 0.0669 | 2.71 (1.47 to 5.24) | 0.0021 | 2.49 (1.27 to 5.38) | 0.0124 |
| Sex, male | 0.96 (0.70 to 1.32) | 0.7837 | 1.01 (0.68 to 1.52) | 0.9789 | 3.12 (0.43 to 33.96) | 0.2770 | 0.68 (0.35 to 1.36) | 0.2609 | 1.17 (0.69 to 2.08) | 0.5709 |
| Type of transplant, bilateral | 0.75 (0.55 to 1.00) | 0.0569 | 0.87 (0.61 to 1.26) | 0.4688 | 0.08 (0.00 to 0.97) | 0.0908 | 0.73 (0.36 to 1.41) | 0.3552 | 1.06 (0.61 to 1.89) | 0.8497 |
| Corticosteroids at time of transplantation | 1.50 (1.04 to 2.24) | 0.0378 | 1.14 (0.74 to 1.79) | 0.5691 | 0.76 (0.41 to 1.45) | 0.3896 | 1.78 (0.96 to 3.43) | 0.0740 | ||
| Antifibrotics at time of transplantation | 0.86 (0.40 to 1.61) | 0.6614 | 1.05 (0.47 to 2.10) | 0.8937 | 1.21 (0.52 to 2.55) | 0.6425 | ||||
| 6MWT at assessment, < 275 m |
1.38 (0.99 to 1.92) | 0.0572 | 1.38 (0.97 to 1.97) | 0.0774 | 1.73 (0.23 to 12.53) | 0.5744 | 0.76 (0.43 to 1.36) | 0.3544 | 1.71 (1.02 to 2.88) | 0.0432 |
| Primary lung disease | ||||||||||
| IPF | Reference | Reference | Reference | Reference | Reference | |||||
| Fibrotic NSIP | 2.07 (1.15 to 3.50) | 0.0099 | 2.61 (1.40 to 4.60) | 0.0015 | 4.25 (1.49 to 10.53) | 0.0032 | 1.86 (0.80 to 3.95) | 0.1218 | ||
| CTD-ILD | 1.43 (0.70 to 2.61) | 0.2766 | 2.11 (0.96 to 4.16) | 0.0435 | 2.52 (0.57 to 7.82) | 0.1526 | 1.99 (0.77 to 4.56) | 0.1222 | ||
| cHP | 0.90 (0.41 to 1.74) | 0.7844 | 1.01 (0.44 to 2.01) | 0.9736 | 1.04 (0.24 to 3.10) | 0.9474 | 0.69 (0.22 to 1.75) | 0.4657 | ||
| Sarcoidosis | 0.64 (0.36 to 1.07) | 0.1113 | 0.96 (0.45 to 1.87) | 0.9246 | 0.09 (0.00 to 1.27) | 0.1068 | 0.74 (0.26 to 1.79) | 0.5347 | 0.88 (0.21 to 2.58) | 0.8397 |
| Others | 1.34 (0.74 to 2.25) | 0.3017 | 1.56 (0.83 to 2.72) | 0.1411 | 1.50 (0.52 to 3.77) | 0.4096 | 2.14 (0.78 to 5.24) | 0.1111 |
Significant p-values are highlighted in bold.
aHR, adjusted HR; cHP, chronic hypersensitivity pneumonitis; CTD-ILD, connective tissue disease-related interstitial lung disease; IPF, idiopathic pulmonary fibrosis; 6MWT, 6 min walk test; NSIP, non-specific interstitial pneumonia.