Table 3.

Number of events, person-years, crude incidence rates (95% CL) and HR (95% CI) obtained from Cox regression comparing each TNFi with etanercept for the combined outcome (any neuroinflammatory event) and in patients with RA

	Events, n	Person-years	Crude incidence rates per 1000 person-years (95% CL)	Meta-analysis HR (95% CI)
TNFi
Etanercept	47	137 135	0.34 (0.26–0.46)	Reference
Adalimumab	36	97 840	0.37 (0.27–0.51)	1.03 (0.65 to 1.62)
Certolizumab pegol	10	21 123	0.47 (0.25–0.88)	1.40 (0.68 to 2.90)
Golimumab	5	14 289	0.35 (0.15–0.84)	1.08 (0.37 to 3.16)
Infliximab	36	98 468	0.37 (0.26–0.51)	1.06 (0.67 to 1.70)

CL, confidence limits; RA, rheumatoid arthritis; TNFi, tumour necrosis factor inhibitor.