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. 2023 Feb 28;30(1):2184307. doi: 10.1080/10717544.2023.2184307

Figure 9.

Figure 9.

Estimation of pro-inflammatory, anti-inflammatory, and bone erosion markers in FCA-induced RA rats. Effect of dual-drug nanoparticles loaded hydrogel on serum pro-inflammatory cytokine levels (A). TNF-α, (B). IL-1β, (C). IL-6 and (D). IL-17A. (E). RANKL (bone erosion marker) (F). IL-10 (anti-inflammatory cytokine). The serum cytokine level in the rat (on day 33) was estimated by ELISA. The data are represented as mean ± SD (n = 4). The values were statistically examined using a one-way ANOVA test. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, and ns- non-significant.

TNF-α: Tumor Necrosis Factor-alpha, IL-1β: Interleukin 1 beta, IL-6: Interleukin 6, IL-17A: Interleukin 17A, RANKL: Receptor activator of nuclear factor-kappa-B ligand and IL-10: Interleukin-10, ELISA: Enzyme-linked immunoassay.