Figure 11.

In vivo anti-arthritis efficacy of dual-drug nanoparticles loaded hydrogel. Histopathological assessment of bone destruction and cartilage damage in RA model. (A). In vivo paw images of the rats from different groups at the endpoint, i.e. 33^rd day. Histological sections with (B). H&E, (C). SO-FG and (D). TB staining of ankle joints in different treatment groups. The red arrow indicates inflammatory cellular infiltration, and the black arrow represents bone erosion and cartilage degradation. Yellow arrows indicate loss of proteoglycan. Scale bar = 200 μm, 100 μm and 25 μm. H&E: Hematoxylin and eosin; SO-FG: Safranin O-fast green; T&B: Toluidine blue.