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. 2022 Nov 23;22(6):705–717. doi: 10.1080/15384101.2022.2146839

Figure 5.

Figure 5.

Circ 0008253 induced OXA resistance in gastric carcinoma cells. Gastric carcinoma cells (KATO III and MKN45) were transfected with circ 0008253 overexpression vector or its negative control. (A) Levels of circ 0008253 in gastric carcinoma cells were detected using qRT-PCR. (B) CCK-8 assay was performed. (C)the colony formation assay was performed in gastric carcinoma cells KATO III and MKN45. Gastric carcinoma cells MKN45 were transfected with circ 0008253 overexpression vector or its negative control, followed by subcutaneously injected into nude mice. One week later, mice were injected with 5 mg/kg OXA. Mice were grouped: NC, NC + OXA, circ, circ + OXA. N = 5. (D) the tumor growth was analyzed. (E) Levels of ABCB1 and ABCG2 in gastric carcinoma cells KATO III and MKN45 were determined. ns P >0.05; *P <0.05. A/B: Brown-Forsythe and Welch's ANOVA test followed by Unpaired t with Welch's correction; C/D: Two-way ANOVA followed by Tukey's multiple comparisons test; E: Unpaired t test or Unpaired Welch's t test.